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Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival

doi: 10.1097/01.hjh.0000249702.49854.fa 153 YangL-KTaoY-X

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It has been reported that the excessive ROS generation and metal ions released from internalized metal-based NPs have an impact on multiple cell signaling pathways, mainly including Janus kinase/signal transducers and activators of transcription (JAK-STAT), nuclear factor-kappa-lightchain enhancer of activated B cells (NF-B), Phosphatidylinositol 3-kinase (PI3K)/protein serine threonidase (Akt), mitogen-activated protein kinase (MAPK), and nuclear factor erythroid 2-related factor 2 (Nrf2) (Ko et al., 2016