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If no benefits are evident after a few days, it is prudent to stop and reassess

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Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chrondrocytes

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Detection indicators: bone density (lumbar spine, hip), bone turnover markers (OC, CTX), bone microstructure (number, thickness, and gaps of bone trabeculae), and skeletal mechanical strength