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Among the most flexible regions, we observed more flexibility in modified residues of the mGLP1-DARPin-1 and mGLP1-DARPin-2 fusion proteins compared with the fusion protein containing native GLP-1

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TMates describes treatment pathways that may involve either option

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Biomarker selection for combination studies should include both telomere-focused readouts (Q-FISH, TRF Southern, TRAP assay) and antioxidant/SASP markers (8-OHdG, SA--gal, SASP cytokine multiplex)