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To test whether hepatic CYP8B1 plays a primary role in the regulation of glucose metabolism by T3, we performed a CYP8B1-knockdown experiment using adeno-associated virus (AAV) expressing shRNA specific for Cyp8b1

The similarity in their TMD interaction patterns is consistent with the strong correlation in the impact of TMD mutagenesis for these two agonists (Fig

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The timeline is real, the mechanism is well-characterised, and the results are reproducible when dosing and UV exposure are controlled