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This crosstalk is epitomized by hypoxia-inducible factor-1 (HIF-1), a master regulator of BNIP3/NIX-mediated mitophagy that drives adaptation in hypoxia-related diseases [24, 25]

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Many people do well with roughly 25 to 30 percent of calories from protein to support muscle and egg or sperm health, 25 to 35 percent from healthy fats including omega-3s for hormone support, and the rest from low-glycemic carbohydrates to keep blood sugar steady

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