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In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 1992

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In some trials, improvements in mood appeared independently of changes in HbA1c, pointing to potential neuropsychiatric effects that go beyond glycemic normalization [8,65,66]

Vehicle effects on human stratum corneum absorption and skin penetration

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