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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
Chen MS, Wang SF, Hsu CY, Yin PH, Yeh TS, Lee HC
Usar antes del entrenamiento y despus del bao diario
What changes is the concentration pattern during each week, with lower peaks and higher troughs creating a more stable level throughout the dosing period