2024 perioperative management glp-1 receptor agonists anesthesia How should we approach patients on agonists? Check out this excellent editorial from Dr. Girish Joshi, "Clarifying the Guidelines and Decoding the Enigma: Strategies for Anesthetic of Patients on Glucagon-Like Perioperative management of long-acting glucagon-like

65 In a meta-analysis by He et al, which included 76 RCTs covering more than 100,000 overweight or obese individuals, GLP-1 RA use was reported to increase the risk of gallbladder stones or biliary tract disease by 37% (RR 1.37 [95% CI 1.231.52])

(42), in which pigs were intravenously infused with 7.5 g LPS/kg BW/h for 1 h, showed a peak of plasma IL-10 at 1 h after LPS infusion and a subsequent decrease

Clinical implication The updated FDA labeling for liraglutide and semaglutide highlights the importance of monitoring depressive symptoms or suicidal thoughts, suggesting treatment discontinuation if such ideations occur [87,88]

It can be helpful for patients who are looking to quickly rehydrate, replenish essential nutrients, or boost their overall wellness

The glucagon receptor component unique to retatrutide increases intestinal motility beyond what GLP-1 alone causes