what drugs interact with tirzepatide 3 Interactions: To Avoid When You're Taking Tirzepatide Tirzepatide (Zepbound) for weight loss

In the human body, physiological GLP-1 is rapidly metabolized by dipeptidyl peptidase-4 (DPP-4), resulting in a loss of its activity

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[PubMed: 28677175] [CrossRef] 97

More studies are needed to determine how common and significant the changes are

Studies have suggested that patients with a history of hypothyroidism who lose a significant amount of weight (even as little as 5 to 10 pounds) while taking GLP-1 medications may see a reduction in their TSH (Thyroid Stimulating Hormone) levels