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While endogenous glucagon prevents hypoglycemia, pharmacological GCGR agonism has attracted attention as a therapeutic strategy in obesity and T2D, as it can increase energy expenditure and reduce food intake despite its hyperglycemic properties 31

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Retatrutide produced the largest weight loss of the class up to ~24.2% at 48 weeks in Phase 2 so the absolute amount of lean mass lost can be larger simply because total loss is larger

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