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[14] initially tested the roles of NNMT in gluconeogenesis and found that NNMT knockdown decreases hepatocyte glucose output, glucose-6-phosphatase catalytic (G6pc) expression, and phosphoenolpyruvate carboxykinase 1 cytosolic ( Pck1 ) expression in primary hepatocytes

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[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

By promoting a more robust metabolic function, this promising compound could potentially address age-related changes in body composition and metabolism, such as increased fat tissue as fat cells grow larger

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