A newly identified safety signal, based on a small number of case reports, indicates a possible association between GLP-1 receptor agonists (including tirzepatide) and suicidal ideation
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Recent evidence suggests that intentional weight loss in older adults with overweight and obesity is effective and safe, hence a diminishing reluctance to use AOMs in this more vulnerable population
In one clinical trial , participants lost 11.2% of their body weight with 15 mg of tirzepatide, compared to 5.7% of weight with 1 mg of semaglutide