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Niacinamide also helps limit how much of that pigment makes it to the skins surface, so youre not just fading spots, but helping prevent new ones from fully forming

doi: 10.3969/j.issn.1672-2159.2022.02.017 169

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The NTD structures for all complexes are very similar with C RMSDs between 0.36 and 0.64 (compared to Ent2 as reference between residues 5 and 336: Ent1 = 0.64 , Ent5 = 0.57 , YAP1801 = 0.36 and APL2 = 0.53 ) with the exception of the structure in complex with Apl2 that shows the formation of a terminal helix (residues 337363), transitioning from a helix-turn-helix configuration to an extended, straight helix (Supplementary Fig