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Human trials demonstrate that two weeks of glutathione supplementation (1g daily) significantly reduces exercise-induced blood lactate elevation and prevents the decrease in intermuscular pH that typically occurs during intense physical activity

Furthermore, the autophagy receptor FUNDC1 has been shown to induce mitochondrial fragmentation, in addition to its involvement in the essential role of mitophagy (Yang et al., 2022), which subsequently results in ATP depletion and a significant decline in mitochondrial mass (Wang and Zhou, 2020)

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Inhibiting ACSL4 effectively prevents fibrosis progression and provides protection against the inflammatory environment

However, the limited sample size necessitates additional research to confirm its efficacy in moderate and severe TAO cases