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This preparation of sterile water and benzyl alcohol (BnOH) allows repeated withdrawals to be made from a single 30mL plastic vial

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However, some individuals do experience skin irritation, which may stem from the medication itself, dehydration, rapid weight loss, or underlying skin conditions triggered by metabolic changes

In the SURMOUNT-4 clinical trial, which enrolled 783 adults with obesity to study tirzepatide over a period of 36 weeks, only 53 participants discontinued taking the medication due to side effects

In plain numbers, that often looks like roughly one to three kilograms lost over a few weeks to months