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A major phase 2 trial in the New England Journal of Medicine 1 found: After 24 weeks: Weight loss ranged from 7.2% with the lowest dose of retatrutide to 17.5% with the highest dose (compared to just 1.6% with placebo) After 48 weeks: Participants on the 12 mg dose lost an average of 24.2% of their starting weight (placebo group: only 2.1%) Most participants (64-100%) taking retatrutide achieved meaningful weight loss of 5% or more, while only 27% of placebo takers reached this goal Managing Retatrutide Side Effects The main side effects of retatrutide affect your digestive system: Nausea Vomiting Diarrhea Bloating These effects are usually not severe and tend to lessen as your body adjusts to the medication
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Interestingly, appetite-related sensations were mostly similar to placebo and liraglutide when assessed postprandially after a lunch buffet
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