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512 Skin Aging Of all the organs, the skin is the most conspicuous to display signs of aging or dermal changes, which are due to chronological (intrinsic) and photoaging (extrinsic) mechanisms

Phosphate buffered solution (PBS) and trypsin with 2.21 mM EDTA were purchased from Corning (Manassas, VA)

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6,10,11 However, in severe poisoning, the selectivity for cardiac versus peripheral vascular effects can be profoundly decreased, making the cardiovascular effects less predictable