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Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40

Magn Reson Imaging 28:163170 Zhang R, Wu W, Luo S (2011) Different behaviors of glutathione in aqueous and DMSO solutions: molecular dynamics simulation and NMR experimental study

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De Rosa SC, Zaretsky MD, Dubs JG, et al