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In most cases, weight loss causes internal hormonal shifts which work to decrease movement and increase hunger and appetite as the body tries to return to its previous set point weight

The study was done without any other lifestyle modification or dietary intervention, indicating its effectiveness as a standalone treatment option

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#Signals #ObesityMedicine #GLP1 #MetabolicHealth To view or add a comment, sign in REDEFINE 5: A Step Forward in Obesity Management The Phase 3a REDEFINE 5 trial demonstrated that cagrilintide + semaglutide achieved significantly greater weight loss than semaglutide alone at 68 weeks (18.4% vs 11.9%), highlighting the potential of dual amylinGLP-1 therapy as a next-generation approach to obesity treatment

The timeline does not support this mechanism