Lagan A, Monti N, Fedeli V, Gullo G, Bizzarri M
Modifications to the peptide chain to reduce degradation by DPP-4, combined with acylation to promote non-covalent binding to albumin, resulted in long-acting formulations, enabling their use in clinical practice.3,5 Initially, GLP-1 receptor monoagonists were marketed with the aim of treating type 2 diabetes, harnessing their incretin effect and glucose-dependent mechanism, along with their capacity to reduce body weight and their beneficial effects on associated comorbidities.1,3,5 Subsequently, research shifted its focus to obesity, employing higher doses than those used for diabetes.3,5 This was followed by the development of unimolecular structures with multi-receptor activity, such as GIP/GLP-1 and GLP-1/glucagon (GCG) coagonists, as well as GIP/GLP-1/GCG triagonists
How Does Semaglutide Interact with Dopamine Pathways
In an in vivo study rodent model of autism induced by prenatal exposure to valproic acid was used for evaluating the effects of resveratrol on social behaviors
Thus, human and rodent studies show that GLP-1R activation in reward-related mesolimbic and brainstem nuclei reduces the motivational incentive of the most rewarding stimulus/food available
