The sample included both males and females (68% boys), children with major neurological syndromes, severe developmental delay, sensory impairments, or medical conditions were excluded
However, OIT is not without limitations, including adverse effects and variability in treatment outcomes depending on the criteria used to define success [14, 15]
One common theme of the observed ETC dysfunction in both muscle and fibroblast culture was that complex dysfunction primarily occurred when evaluating the function of complex III with complex I or II, suggesting that it is the interaction between complex III and complex I or II rather than at complex I or II specifically
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