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While FOXO3 has been associated with exceptional longevity in multiple human populations, FOXO1 was found to be associated with longevity traits in female Han Chinese populations [94, 95]

Enrichment analysis also identified pathways less well-recognized as IGF-related, including immune regulator-associated pathways, almost all with negative enrichment scores suggesting pathway inactivation (Supplementary Tables S8-10)

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We found that CD36 was particularly expressed in the PDX coming from TNBC of the LAR subtype, which is known to be more sensitive to ferroptosis [22]