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A study using C57BL/6J mice concluded that B12 supplementation minimally impacts microbial community structure under healthy conditions but does after DSS-induced colitis treatment [46]

Others have used a similar approach to understand how cell development and health are affected by insulin mutations or SNPs derived from monogenic patients, neonatal diabetes patients, and GWAS studies (228238)

Animal studies show it reduces inflammation in colitis models, heals intestinal anastomoses (surgical connections), reverses intestinal perforations, and protects the gut lining from NSAID damage