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In AD, NF-B activation is linked to -amyloid plaque-induced microglial stimulation [445], while in PD, -synuclein aggregates act as DAMPs that activate TLR2 [446]

L-Carnitine functions in conjunction with pantothenic acid or otherwise known as vitamin B5. Vitamin B5 is a important factor of coenzyme A

Third, there is evidence of successful restoration of aberrant mRNA splicing in non-NDD muscular conditions such as Spinal Muscular Atrophy (SMA) [89] and Duchenne Muscular Dystrophy (DMD) [90] through targeting splice junctions and cis-regulatory elements with ASOs [91, 92] (Fig

doi: 10.3389/fnut.2020.00143 Received 26 June 2020 Accepted 21 July 2020 Published 02 September 2020 Volume 7 - 2020 Edited by Christophe Matthys, KU Leuven, Belgium Reviewed by Alan Diamond, University of Illinois at Chicago, United States

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