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To be used: Face

Free Fe 2+ released from Mb degradation catalyzes the production of lipid peroxides through the Fenton reaction, which eventually induces ferroptosis and AKI

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Interestingly, knockdown of HO-1 significantly reduced ACSL4 protein expression in the FAC-treated group compared to the normal FAC-treated group, thereby preventing ACSL4 from catalyzing cellular lipid peroxidation to inhibit ferroptosis, and up-regulated the expression of SLC3A2 and SLC7A11 proteins, while GPX4 protein did not change significantly (Fig

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