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In a Portuguese study, the SELENOS 105G/A promoter polymorphism (rs28665122) was strongly associated with circulating levels of cytokines such as IL-1, IL-6, and TNF-, known to be involved in the pathogenesis of HT ( Reference Schomburg and Kohrle 71 , Reference Santos, Duraes and Mendes 73 )

2019 Oct 1;257:S0165-0327(19)30593-2

[PUBMED Abstract] Teerlink C, Farnham J, Allen-Brady K, et al.: A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q