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This suggests that (-)-Vestitol and Salviolone may provide an alternative or complementary therapeutic strategy, potentially with enhanced efficacy or reduced side effects, owing to its multi-target and possible disease-modifying nature

Indeed, NAMPT and SIRT1 activate OSKM factors and stem signaling pathways, promoting stemness and dedifferentiation from cancer cells to cancer stem-like cells (CSCs)

The good news is that these challenges respond well to a layered approach: diet, lifestyle, medical care where needed, and targeted supplementation

doi:10.1016/S0022-3565(25)05394-7

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