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95% CI, 0.82-0.99) (33)

Early-phase clinical trials have reported substantial reductions in body weight (Jastreboff et al., New England Journal of Medicine , 2023)

Since vitamin B12 is found in many foods, deficiency is more common in the elderly, strict vegetarians, or those who take oral contraceptives or medications for gastric disorders or insulin resistance

Clinical Evidence 2026 Update: Phase 3 TRIUMPH Data In December 2025, Eli Lilly reported the first successful Phase 3 readout for retatrutide (LY3437943) from the TRIUMPH-4 trial

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