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Some of these enzymes require nutrient cofactors [1] (Figure 1)

Curr Opin Pharmacol (2013) 13(6):9415.10.1016/j.coph.2013.09.012 148 BermudezRViglianoFQuirogaMINietoJMBosiGDomeneghiniC

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The Anaemia Problem The second way B12 deficiency affects wound healing is through anaemia

Its anabolic and growth-promoting effects are largely indirect, primarily via stimulation of hepatic IGF-1 production, whilst its direct metabolic effects, particularly those related to lipid metabolism and adipose tissue regulation, are believed to be mediated by specific domains within the GH molecule itself