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The specific doses in the published research focused on demonstrating proof of concept rather than establishing detailed dose-response curves

However, after deterioration with lower-extremity motor weakness and a repeat MRI study revealing an increase in lesion size, the patient underwent bilateral L5 and S1 foraminotomies and bilateral L5 laminectomy with resection of the L5 nerve sheath tumor (intradural and extradural)

Safety Advice Liver Disease No dosage adjustment for Rybelsus is generally needed in patients with mild to moderate hepatic impairment

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Front Cell Neurosci 10:214