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Beyond its energy role, NAD+ is the essential substrate of sirtuins (SIRT1-SIRT7), deacetylases that regulate mitochondrial biogenesis, DNA repair, and resistance to cellular stress (Imai & Guarente, Trends Cell Biol 2014)

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Medicinal benefits, biological, and nanoencapsulation functions of riboflavin with its toxicity profile: a narrative review