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Unlike the controlled response seen in acute stress, this prolonged activation is unregulated and leads to a proinflammatory environment in the brain

In saline-treated rats, Dox exposure caused sarcolemmal vacuolization, myofibrillar fragmentation, and extensive mitochondrial injury, including swelling, cristae disruption, and membrane dilation

3 Endocrinology / Metabolism ReviewIGF-1 receptor signalling, insulin-like metabolic effects and glucose handling

Manganese also supports the formation of collagen, which is required for optimal cartilage structure and integrity

Originally proposed in HA-based micellar systems for tumor-targeted delivery, this mechanismspatial CD44-mediated localization of HA and ROS-triggered temporal GSH releaseis directly applicable to wound healing