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Interestingly, elevated baseline levels of inflammatory markers such as CRP and IL-6 have been linked to both increased risk and severity of anxiety (Mac Giollabhui et al., 2025), while epidemiological data show that individuals with inflammatory autoimmune diseases like psoriasis have increased risks of experiencing developing anxiety disorders (Lee et al., 2025)

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However, it is important to note that NDD therapeutics may face more obstacles in clinic than the retinal delivery of Luxturna as the brain is less accessible than the eye and requires the delivery vector to cross the blood-brain barrier (BBB)

Therefore, this study is the first to evaluate the optimal addition level of TAs in grass carp, providing a scientific foundation for the advancement of novel functional feed additives