Muscle fibres can be divided into: slow , consisting of type I fibres mainly, which generate energy principally from oxidative metabolism, are less dependent on anaerobic glycolysis, are tonic active and very resistant to fatigue
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By targeting multiple mechanismssuch as enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satietyGLP-1 RAs provide significant improvements in glycemic control, weight reduction, and long-term cardiovascular and renal health (6)(16)(23)
These discrepancies may reflect species-specific differences that include the relative accessibility and importance of GLP-1R circuits in the CNS compared with those in the peripheral nervous system for controlling appetite, or these discrepancies may be due to other limitations, including the dose, potency, pharmacokinetics, and selectivity of the antagonist used and the short-term observation period