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Trimethylamine-N-oxide promotes fibrotic activation of quiescent valvular interstitial cells via endoplasmic reticulum stress

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But the gap between what patients fear and what the trial data shows is substantial

This is the opposite of the antagonistic relationship seen with ibuprofen

A brief weekly survey sent through a secure channel can reveal early signs of trouble, like nausea that signals a need to lower the dose, and the patient avoids a full appointment