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-Glutamylcysteine ligase (GCL) is the rate limiting enzyme involved in GSH synthesis and its expression has been shown to be induced in response to CS [13]

Eating smaller, more frequent meals instead of large meals can also reduce reflux

Experimental example Using erastin-treated A549 cells, we measured intracellular Fe 2+ , ROS, lipid peroxide, glutathione, glutamate release into the extracellular space, and cystine uptake