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Targeting apoptotic and survival signalling nodes, including pharmacological activation of PI3K/Akt/mTOR or strategies aimed at restoring BDNF expression or TrkB activation, therefore offers promising neuroprotective avenues in alcohol-related CNS disorders [41,48,86] (Figure 4)

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Benefits may appear within a few weeks of consistent intake, depending on diet quality, lifestyle, metabolism, and overall health condition

[8] However, these findings come from limited, early-phase human studies and should not be taken as established clinical evidence