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3.1.1 Background MDD is characterized by constant depressed mood, anhedonia, altered sleep and appetite, fatigue, guilt, hopelessness, and suicidal tendencies (Cui et al., 2024)

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It meets the 99.0% specification

Unpredictable pharmacology : The dose-response relationship for both efficacy and safety has not been characterised at very low doses, creating uncertainty about what effectsbeneficial or harmfulmight occur

We cant just focus on the number of patients on GLP-1s, but must look to the number of patients having been on GLP-1s for long enough that second-order effects (including negative ones) will begin making themselves known beyond a doubt