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In AMPK1/ HepG2 cells, the stimulating effects of BBR on the activity p-AMPK1, p-AMPK and AMPK, and its effects on glucose and lipid metabolism, are completely suppressed (Ren et al., 2020)

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In other words, treating an adolescents obesity can improve their overall health now and in the future because obesity increases the risk of serious health problems, including cardiovascular disease, hypertension (high blood pressure), diabetes mellitus, and certain types of cancer