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The Nrf2/HO-1 signaling cascade emerges as a crucial therapeutic target in H/R-induced OS management

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IL-1, for example, increases AAV transduction efficiency in human synovial cells, suggesting that the OA microenvironment may be leveraged to improve delivery (183)

Comprehensive Cellular Protection Beyond just cleaning up, glutathione acts as a shield for the most sensitive parts of the cell: DNA Protection: It prevents oxidative damage to DNA, reducing the risk of mutations

However, the immune response of the CNS is complex and involves a myriad of diverse cell populations such as astrocytes, microglia, macrophages, NK cells, and T and B cells (Aoyama, 2021)