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Common Side Effects Headache Dry mouth Nausea Insomnia Sore throat Changes in taste Constipation Increased sweating Weight changes Serious Side Effects (Seek Immediate Medical Attention) Seizure risk, especially at higher doses Elevated blood pressure or heart rate Suicidal thoughts or behavior, especially in young adults Severe allergic reaction Mania or hypomania Worsening angleclosure glaucoma Sexual dysfunction (lower risk than other antidepressants) Drug Interactions Inform your healthcare provider about all medications you take, including: SSRIs, SNRIs, TCAs, MAOIs Blood pressure medications Antiviral agents Anticoagulants Antidiabetic drugs Antipsychotics Antiepileptics Steroids Parkinsons medications Sleep aids Precautions Discuss the following conditions with your provider before starting Wellbutrin: Seizure disorder Eating disorders Head injury or CNS tumor Glaucoma Heart disease or high blood pressure Diabetes Bipolar disorder Substance use history Kidney or liver disease Pregnancy or breastfeeding Sources Prescribers Digital Reference

This contrasts with the mechanism of HDACi (SAHA) found in previous studies

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Structural basis of FFAT motif-mediated ER targeting

Weight loss was also aided by taking 2 grams (g) of L-carnitine daily for at least two weeks, However, further study is required to determine its potential effects on long-term weight loss