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Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from Guinea pig pancreas

LA and/or ALC stimulated mitochondrial biogenesis, up-regulated the expression of PGC-1 and reduced the production of ROS during the 4-week pretreatment Since LA and ALC were withdrawn after a 4-week pretreatment, the question arose as to whether they actively enhanced the antioxidant defence systems for cells to be resistant to the ensuing 4-week rotenone challenge

This activation initiates intracellular signaling cascades, primarily through cyclic AMP (cAMP) and protein kinase A (PKA) pathways