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Lancet 377:19291937 Creager MA, Olin JW, Belch JJ, Moneta GL, Henry TD, Rajagopalan S, Annex BH, Hiatt WR (2011) Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication

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This decline has led some researchers to speculate that reduced GHK signaling could contribute to age-related impairments in: wound healing tissue repair collagen production While this hypothesis remains under investigation, it helps explain why GHK-Cu supplementationparticularly through topical formulationshas become a focus of dermatologic research

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Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I