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In the long-term toxicity experiment, continuous injection of AOD 9604 (10 mg/kg) for 8 weeks did not cause abnormal liver and kidney functions or fluctuations in blood glucose, providing a safety basis for its further research and application

This apparent safety in rodents spanning 30+ years of research from multiple independent laboratories is genuine

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Being honest about that gap is not a weakness of this guide it is the accurate picture, and it is why every dosing figure here is framed as a research protocol rather than a recommendation