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[86] In 1907, an animal model that would eventually help to isolate and identify the "antiscorbutic factor" was discovered

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In an in-vitro study by Sevostyanova et al., 2002, short peptides including Epithalon and the related Vilon activated the synthesis of interleukin-2 mRNA in mouse spleen cells (splenocytes), and did so without the specific inducers otherwise required

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113 , 114 , 115 , 116 Although comparisons between different studies are limited, the proportion of patients who experienced hyperpigmentation was greater than that among those treated with afamelanotide