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Pharmacokinetic studies revealed [6] : Orally administered AOD9604 was well absorbed in pigs with rapid degradation kinetics Primary degradation products were peptide fragments missing 2-3 amino acids from termini Both degradation products retained some reduced anti-lipogenic activity Rat whole-body radiography showed similar organ distribution patterns following both intravenous and oral administration This distribution pattern supports systemic absorption via the oral route in laboratory models

(2020) 9:S2433

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10, 11, 12, 14, 15, 16, 17 This animal model provides an understanding of how exogenous agents, such as PPA, can cause reversible behavioral, metabolic, neuropathological and neurophysiological changes associated with ASD