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Spironolactone continues to be valuable for androgen-mediated symptoms like hirsutism and acne, even while tirzepatide reduces testosterone production

Lazaridis I, Tzortzi O, Weglage M, Mrtin A, Xuan Y, Parent M, et al

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The pivotal finding is that palmatine orchestrates a coordinated downregulation of this entire network, and this multi-target action functionally converges to suppress the core executioners of hepatocyte apoptosis