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What the Research Shows This warning exists because, during early laboratory trials, researchers found that semaglutide caused thyroid C-cell tumours in rats and mice

Most often, decreasing the dose or pausing therapy will improve minor-to-moderate gastrointestinal symptoms

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By coupling agonism at the GLP-1 receptor with simultaneous agonism at the GIP receptor, a related incretin whose physiological role had been the subject of decades of competing theories, Eli Lilly produced a molecule whose efficacy in trial conditions exceeded semaglutide by a margin too large to dismiss as noise or trial-design artifact

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