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Description Reviews (0) Research Use Only (RUO)

Abstract Background This systematic review and network meta-analysis aimed to evaluate the three different administration routes of vitamin B12: oral, intramuscular (IM), and sublingual (SL) routes

The primary outcome is the presence of at least three-step Early Treatment Diabetic Retinopathy Study (ETDRS) stage progression

It is synthesised in the cytosol by glutamate-cysteine ligase (EC 6.3.2.2) and glutathione synthetase, with the first, rate-limiting step feedback-inhibited by glutathione itself and intracellular concentrations typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999)

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