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In established tumors, TAMs can further promote immunosuppression and tumor progression by producing pro-angiogenic factors, such as VEGF, and by releasing IL-10-rich signals that impair effective cytotoxic T-cell responses (126)

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Common risk factors for both, including obesity, diabetes, dyslipidemia, hypertension, and metabolic syndrome, are likely drivers of this association

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Turan et al., 2021 )

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